Serum immune complexes as diagnostic and therapeutic markers in lymphatic filariasis
Identifieur interne : 007456 ( Main/Exploration ); précédent : 007455; suivant : 007457Serum immune complexes as diagnostic and therapeutic markers in lymphatic filariasis
Auteurs : Vandana Dixit [Inde] ; A. K. Gupta [Inde] ; P. S. Bisen [Inde] ; G. B. K. S. Prasad [Inde] ; B. C. Harinath [Inde]Source :
- Journal of Clinical Laboratory Analysis [ 0887-8013 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Antigènes d'helminthe (immunologie), Complexe antigène-anticorps (sang), Diéthylcarbamazine (usage thérapeutique), Filaricides (usage thérapeutique), Filariose lymphatique (diagnostic), Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Humains, Marqueurs biologiques (sang), Porteur sain (diagnostic), Porteur sain (sang), Porteur sain (traitement médicamenteux), Test ELISA, Tests sérologiques, Wuchereria bancrofti (immunologie).
- MESH :
- diagnostic : Filariose lymphatique, Porteur sain.
- immunologie : Antigènes d'helminthe, Wuchereria bancrofti.
- sang : Complexe antigène-anticorps, Filariose lymphatique, Marqueurs biologiques, Porteur sain.
- traitement médicamenteux : Filariose lymphatique, Porteur sain.
- usage thérapeutique : Diéthylcarbamazine, Filaricides.
- Animaux, Humains, Test ELISA, Tests sérologiques.
English descriptors
- KwdEn :
- Animals, Antigen-Antibody Complex (blood), Antigens, Helminth (immunology), Biomarkers (blood), Carrier State (blood), Carrier State (diagnosis), Carrier State (drug therapy), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (drug therapy), Enzyme-Linked Immunosorbent Assay, Filaricides (therapeutic use), Humans, Serologic Tests, Wuchereria bancrofti (immunology).
- MESH :
- chemical , blood : Antigen-Antibody Complex, Biomarkers.
- chemical , immunology : Antigens, Helminth.
- blood : Carrier State, Elephantiasis, Filarial.
- diagnosis : Carrier State, Elephantiasis, Filarial.
- drug therapy : Carrier State, Elephantiasis, Filarial.
- immunology : Wuchereria bancrofti.
- chemical , therapeutic use : Diethylcarbamazine, Filaricides.
- Animals, Enzyme-Linked Immunosorbent Assay, Humans, Serologic Tests.
Abstract
In the present study we examined the utility of measuring antigen‐specific soluble immune complexes (ICs) for the differential diagnosis and therapeutic monitoring of Bancroftian filariasis. Antigen‐specific ICs were detected in significantly elevated levels in 90% of lymphatic filarial subjects suffering from disease manifestations, and very low levels in 8–10% of microfilaria (MF) carriers. The high incidence of antigen‐specific ICs in the circulation of filarial subjects with clinical manifestations in contrast to the negligible presence in MF carriers facilitates serological differentiation of these two important stages of lymphatic filarial infection. A sudden spurt in circulating levels of antigen‐specific ICs was recorded in all MF carriers on diethylcarbamazine (DEC) therapy, and the magnitude of the increase correlated positively with the pretreatment levels of circulating MF. Thus, it is evident from the present study that circulating ICs (CICs) are potential serological markers for both the differential diagnosis of filarial infection and therapeutic monitoring of MF carriers. J. Clin. Lab. Anal. 21:114–118, 2007. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jcla.20116
Affiliations:
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Antigen‐specific ICs were detected in significantly elevated levels in 90% of lymphatic filarial subjects suffering from disease manifestations, and very low levels in 8–10% of microfilaria (MF) carriers. The high incidence of antigen‐specific ICs in the circulation of filarial subjects with clinical manifestations in contrast to the negligible presence in MF carriers facilitates serological differentiation of these two important stages of lymphatic filarial infection. A sudden spurt in circulating levels of antigen‐specific ICs was recorded in all MF carriers on diethylcarbamazine (DEC) therapy, and the magnitude of the increase correlated positively with the pretreatment levels of circulating MF. Thus, it is evident from the present study that circulating ICs (CICs) are potential serological markers for both the differential diagnosis of filarial infection and therapeutic monitoring of MF carriers. J. Clin. Lab. Anal. 21:114–118, 2007. © 2007 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Dixit, Vandana" sort="Dixit, Vandana" uniqKey="Dixit V" first="Vandana" last="Dixit">Vandana Dixit</name></noRegion><name sortKey="Bisen, P S" sort="Bisen, P S" uniqKey="Bisen P" first="P. S." last="Bisen">P. S. Bisen</name><name sortKey="Gupta, A K" sort="Gupta, A K" uniqKey="Gupta A" first="A. K." last="Gupta">A. K. Gupta</name><name sortKey="Harinath, B C" sort="Harinath, B C" uniqKey="Harinath B" first="B. C." last="Harinath">B. C. Harinath</name><name sortKey="Prasad, G B K S" sort="Prasad, G B K S" uniqKey="Prasad G" first="G. B. K. S." last="Prasad">G. B. K. S. Prasad</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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